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APOE: Linked to lipid metabolism and Alzheimers risk

doi: 10.3389/fendo.2025.1714219 Received 27 September 2025 Revised 17 December 2025 Accepted 18 December 2025 Published 14 January 2026 Volume 16 - 2025 Edited by Herbert F

Gammone et al

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DNA methyltransferase 1-mediated modifications exhibit bidirectional effects: hypermethylation of promoter regions in protective genes, such as ACTN4 (encoding -actinin-4), suppresses their expression, while hypomethylation of pro-pathogenic genes, including matrix metalloproteinase-9, enhances their transcription (67, 68)